Age-Dependent Changes in Bone Architecture, Patterning, and Biomechanics During Skeletal Regeneration
Mouse digit amputation provides a useful model of bone growth after injury, in that the injury promotes intramembranous bone formation in an adult animal.The digit tip is composed of skin, nerves, blood vessels, bones, and tendons, all of which regenerate after digit tip amputation, making it a powerful model for hyfrodol multi-tissue regeneration.